Amprolium API CAS: 121-25-5
Information: Amprolium has good activity against Eimeria tenella, E. acervulina in poultry and can be used as a therapeutic agent for these organisms. It only has marginal activity or weak activity against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in combination with other agents (e.g., ethopabate) to improve control against those organisms.
In cattle, amprolium has approval for the treatment and prevention of E. bovis and E. zurnii in cattle and calves. Amprolium has been used in dogs, swine, sheep, and goats for the control of coccidiosis, although there are no approved products in the U.S.A. for these species.
By mimicking its structure, amprolium competitively inhibits thiamine utilization by the parasite. Prolonged high dosages can cause thiamine deficiency in the host and excessive thiamine in the diet can reduce or reverse the anticoccidial activity of the drug.
Amprolium reportedly acts primarily upon the first generation schizont in the cells of the intestinal wall, preventing differentiation of the metrozoites. It may also suppress the sexual stages and sporulation of the oocysts.
Synonyms: Pyridinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride
Molecular Formula: C14-H19-Cl-N4